Pleiotropic effects of prokineticin 2 in the control of energy metabolism

Prokineticins are family of small proteins involved in many important biological processes including food intake and control energy balance. The prokineticin 2 (PROK2) is expressed several peripheral tissues areas the central nervous system. PROK2 activates G protein-coupled receptors, namely, receptor 1 (PROKR1) (PROKR2). Preclinical models exhibiting disturbances pathway (at level or its receptors) characterized by changes intake, feeding behavior insulin sensitivity related to a dysfunction balance control. In Humans, mutations PROKR2 genes associated Kallmann syndrome (KS) that affects both hormonal reproductive axis sense smell may also lead obesity. Moreover, plasma concentration has been correlated with various cardiometabolic risk factors type diabetes (T2D). present review summarizes knowledge on structure, signaling function focusing role homeostasis.